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How NexGard® and NexGard® PLUS Works In Dogs

The active ingredient in NexGard® is afoxolaner, which belongs to a newer class of flea and tick preventatives called isoxazolines. Isoxazolines eliminate fleas and ticks by over-exciting their nervous system, causing paralysis and death.

Nexgard® PLUS contains afoxolaner and includes two additional anti-parasitic medications: moxidectin, which adds heartworm, hookworm, and roundworm prevention, and pyrantel, a dewormer for hookworms and roundworms. Moxidectin works by causing an electrolyte overload in the nervous system of worms, resulting in paralysis and death. Pyrantel works by blocking receptors in the nervous system of worms to cause paralysis and death.