空肠弯曲菌噬菌体的应用：挑战和前景,Animals
空肠弯曲菌噬菌体的应用：挑战和前景
Animals
(
IF
2.7
)
Pub Date : 2020-02-11
, DOI:
10.3390/ani10020279
Leonid Ushanov
,
Besarion Lasareishvili
,
Irakli Janashia
,
Andreas E. Zautner
噬菌体（噬菌体）是生物圈中数量最多，地面清洗13825404095种类最多的生物实体。由于在过去十年中多药耐药细菌菌株的兴起，噬菌体目前正引起新的兴趣。噬菌体及其衍生物在医学和生物技术领域的潜力正在得到积极研究。目前，针对致病性食源性细菌的噬菌体应用正在用于活体牲畜的去污和治疗，并在收获后水平用作生物防治措施。对于这种适应症，美国食品和药物管理局（FDA）已批准了几种针对李斯特菌属，沙门氏菌属的噬菌体产品。和大肠埃希氏 大肠杆菌。基于噬菌体的空肠弯曲 菌应用可能与抗沙门氏菌类似。和李斯特菌属；然而，迄今为止，只有极少数弯曲杆菌噬菌体产品被批准用于任何地方。迄今为止对弯曲杆菌噬菌体的研究表明，空肠弯曲杆菌亚群的高度多样性以及噬菌体的分离和富集程序都会影响弯曲杆菌噬菌体的特异性和功效。这篇综述文章强调了以前发现的结论，这些结论有助于分离弯曲杆菌 噬菌体并提高分离物的特异性和功效。
"点击查看英文标题和摘要"
Application of Campylobacter jejuni Phages: Challenges and Perspectives
Bacteriophages (phages) are the most abundant and diverse biological entities in the biosphere. Due to the rise of multi-drug resistant bacterial strains during the past decade, phages are currently experiencing a renewed interest. Bacteriophages and their derivatives are being actively researched for their potential in the medical and biotechnology fields. Phage applications targeting pathogenic food-borne bacteria are currently being utilized for decontamination and therapy of live farm animals and as a biocontrol measure at the post-harvest level. For this indication, the United States Food and Drug Administration (FDA) has approved several phage products targeting Listeria sp., Salmonella sp. and Escherichia coli. Phage-based applications against Campylobacter jejuni could potentially be used in ways similar to those against Salmonella sp. and Listeria sp.; however, only very few Campylobacter phage products have been approved anywhere to date. The research on Campylobacter phages conducted thus far indicates that highly diverse subpopulations of C. jejuni as well as phage isolation and enrichment procedures influence the specificity and efficacy of Campylobacter phages. This review paper emphasizes conclusions from previous findings instrumental in facilitating isolation of Campylobacter phages and improving specificity and efficacy of the isolates.