肠道细菌易位的研究进展,Microbial Pathogenesis
在正常情况下，肠道菌群和身体处于动态平衡。当由于各种原因导致肠道屏障功能受损时，细菌数量和比例的变化或空间位移会导致细菌移位（BT），最终导致多器官功能障碍综合征（MODS）。肠道菌群和内毒素易位引起的内源性感染和内毒素血症是炎症反应的起源，而肠道是MODS发起和靶向的器官。只有确保肠粘膜屏障的完整性，才能有效预防肠BT。消除原发疾病并维持肠道的血液和氧气供应是最基本的治疗方法。肠道的早期启动，建立肠内营养以及选择性消化去污也是非常有效的治疗方法。BT的早期诊断，干预或预防可能是治疗各种疾病的新途径或重要联系。综述了BT的作用机理，检测技术，防治方法及其与肠胃外疾病的相互作用。
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Current progress of research on intestinal bacterial translocation
Under normal conditions, the intestinal flora and the body are in dynamic equilibrium. When the barrier function of the intestinal tract is damaged due to various reasons, changes in the number and proportion of bacteria or spatial displacement result in bacterial translocation (BT), which ultimately leads to multiple organ dysfunction syndrome (MODS). Endogenous infections and endotoxemia caused by intestinal flora and endotoxin translocation are the origins of inflammatory responses, and the intestinal tract is the organ in which MODS both initiates and targets. Only by ensuring the integrity of the intestinal mucosal barrier can intestinal BT be effectively prevented. Elimination of the primary disease and maintaining blood and oxygen supply to the intestine is the most basic treatment. Early initiation of the intestinal tract, establishment of enteral nutrition, and selective digestive decontamination are also highly effective treatments. Early diagnosis, intervention, or prevention of BT may be a new avenue or important connection in the treatment of various diseases. The mechanism of BT, detection techniques, prevention and treatment, and its interaction with parenteral diseases were reviewed.